Huntington’s disease is an inherited disorder that includes brain cell death. In the initial stage, the person struggles with mood disorder and mental disability followed by trembling posture. As the disease progresses, the body shows lack of coordination and in the last stage, dementia occurs.
CBD oil has the potential to help in treating Huntington’s according to research. CBD or cannabidiol is extracted from cannabis Sativa or hemp and then blended with a carrier oil for dilution. CBD binds with your body’s endocannabinoid system that is responsible for major psychological responses.
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Benefits of CBD oil on Huntington’s
HD is a neurodegenerative condition. It is a genetic disorder caused by autosomal dominant mutation. Basal ganglia in the brain are responsible for motor function. It gets affected due to HD development.
The normal brain areas interact with brain protein only, but the mutated version blocks this interaction causing neuronal loss and cell death. While treating HD, the priority is to protect nerve cells present in the striatum.
The research reported that CBD improves the nerve ending [synaptic] plasticity and prevents neuronal abnormalities thus the neurodegenerative damage due to HD gets weakened.
HD causes neuron loss and motor function impairment. The neuronal loss increases glutamate level that is toxic to the mitochondria, thus free radicals get formed. The free radicals hold highly reactive unpaired electrons, so can cause damage to the cellular structure.
They are immune responses but can contribute to aggravating the disease if they get indiscriminately formed. Free radicals cause oxidative damage to the cellular protein breathing them down to death.
Antioxidants help to hunt the free radicals and terminate them. Studies show that CBD is a neuroprotective agent that reduces glutamate toxicity and free radical damage.
The inflammatory response gets suppressed
Inflammation response involves swelling, heat, redness, and pain due to pathogenic invasion or any kind of injury. It is a natural protection mechanism the immune system employs towards external threats or damages by discharging mediators, which fight the infection.
Chronic inflammation can obstruct the natural injury healing process. Usually, an inflammatory response is against the foreign object and in mutated huntingtin protein the glutamine tract is identified as a threat and chronic inflammation gets initiated to get rid of it. Microglia cells remove the brain’s unwanted debris and dying neurons.
During HD the microglia activities increase and they overcome the neighboring neurons with huntingtin protein. Microglia employs multiple mediators like cytokines, complement proteins, free radicals, and proteases to apply inflammatory responses and persistently degrade the nerve cells. In treating HD, there is a need for anti-inflammatory therapy to stop the mediators.
CBD’s anti-inflammatory property helps to regulate several brain areas that delay HD progression.