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Gopal Bhatnagar based in Toronto, Canada invented a 3D printed adapter to turn a traditional hookah into an e-hookah. It is used as an alternative of the ceramic bowl that contains shisha tobacco. Several companies including Canada’s Eagle Energy Vapor are selling caffeine-based e-cigarettes as an alternative of containing nicotine. Hon Lik registered a patent for the fashionable e-cigarette design in 2003.

In 1996, California turned the primary U.S. state to legalize medical cannabis in defiance of federal legislation. In 2001, Canada became the primary country to adopt a system regulating the medical use of cannabis. There is critical suspicion among cardiologists, spurring analysis however falling short of definitive proof, that hashish use has the potential to contribute to cardiovascular disease. Cannabis is believed to be an aggravating think about rare circumstances of arteritis, a severe condition that in some cases results in amputation. Because 97% of case-reports additionally smoked tobacco, a proper affiliation with cannabis could not be made. If arteritis turns out to be a distinct medical entity, it may be the consequence of vasoconstrictor activity observed from delta-8-THC and delta-9-THC. Other serious cardiovascular events together with myocardial infarction, stroke, sudden cardiac dying, and cardiomyopathy have been reported to be temporally related to cannabis use.

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Effective October 1, 2015, vaping is prohibited in all smoke-free areas, which included bars and eating places. Instead, vaping is prohibited on all campuses of state-supported establishments of higher education, together with buildings, grounds, parking heaps, and vehicles owned by establishments. Enclosed research laboratories are exempt, as properly as bars, eating places, workplaces and all different indoor places where smoking is banned under the Illinois Clean Indoor Air Act. BLOW started promoting e-hookahs, an electronic version of the hookah, in 2014. The deal with of every hose for the e-hookah contains a heating component and a liquid, which produces vapor.

Synthetic cannabinoids can be found for prescription use in some countries, corresponding to dronabinol and nabilone. Countries that allow the medical use of whole-plant cannabis embrace Australia, Canada, Chile, Colombia, Germany, Greece, Israel, Italy, the Netherlands, Peru, Poland, Portugal, and Uruguay. In the United States, 36 states and the District of Columbia have legalized cannabis for medical purposes, starting with the passage of California’s Proposition 215 in 1996. Although hashish stays prohibited for any use on the federal stage, the Rohrabacher–Farr modification was enacted in December 2014, limiting the flexibility of federal legislation to be enforced in states the place medical hashish has been legalized. Short-term use increases the chance of minor and main opposed results.

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Some have advocated bans on e-cigarette gross sales and others have advised that e-cigarettes may be regulated as tobacco products however with less nicotine content material or be regulated as a medicinal product. A 2016 World Health Organization report discovered that the scientific evidence for the effectiveness of vaping for quitting smoking is “scant and of low certainty”. Healthcare organizations within the UK in 2015 have inspired people who smoke to try e-cigarettes to help them quit smoking and also inspired e-cigarette users to give up smoking tobacco completely. While advertising of tobacco merchandise is banned in most nations, tv and radio e-cigarette promoting in several nations may be not directly encouraging conventional cigarette use. E-cigarette commercials are additionally in magazines, newspapers, on-line, and in retail shops. Between 2010 and 2014, e-cigarettes had been second only to cigarettes as the top marketed product in magazines.
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Also, gross sales, presents and furnishing of vapor products to persons beneath the age of 18 are topic to authorized action the identical way as if it were alcohol to an individual underneath 21. Instead, vaping is simply prohibited in state and native authorities buildings, facilities of state colleges and universities, facilities licensed by Commissioner of Human Services, and amenities licensed by Commissioner of Health. All other indoor locations topic to the Minnesota Clean Indoor Air Act, including bars and restaurants, are totally exempt from the state’s regulation.

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Nicotine, a key ingredient in most e-liquids, is well-recognized as some of the addictive substances, as addictive as heroin and cocaine. Addiction is believed to be a dysfunction of experience-dependent mind plasticity. The reinforcing results of nicotine play a significant position at first and continuing use of the drug. First-time nicotine customers develop a dependence about 32% of the time. Chronic nicotine use entails each psychological and physical dependence. Nicotine-containing e-cigarette vapor induces addiction-related neurochemical, physiological and behavioral changes. Nicotine impacts neurological, neuromuscular, cardiovascular, respiratory, immunological and gastrointestinal techniques.
They are marketed to males, girls, and children as being safer than conventional cigarettes. There are growing considerations that e-cigarette advertising campaigns unjustifiably concentrate on younger adults, adolescents, and ladies. Large tobacco companies have significantly elevated their advertising efforts. This advertising pattern could increase the use of e-cigarettes and contribute to re-glamorizing smoking. Some firms may use e-cigarette advertising to advocate smoking, intentionally, or inadvertently, is an area of concern. E-cigarettes are promoted to a sure extent to forge a vaping tradition that entices non-smokers. Themes in e-cigarette advertising, together with sexual content and buyer satisfaction, are parallel to themes and methods which are appealing to youth and younger adults in traditional cigarette advertising and promotion.
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Typically, adverse effects of medical hashish use are not severe; they include tiredness, dizziness, elevated urge for food, and cardiovascular and psychoactive effects. Other effects can embrace impaired short-term memory; impaired motor coordination; altered judgment; and paranoia or psychosis at excessive doses. Tolerance to those effects develops over a period of days or weeks. Withdrawal signs are not often a problem with managed medical administration of cannabinoids. The capability to drive automobiles or to function equipment may be impaired until a tolerance is developed.

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Juul was spun off from Pax Labs in June 2017 and is now out there by the independent firm Juul Labs. The eTron 3T from Vapor Tobacco Manufacturing, launched in December 2014, employs a patented, aqueous system whereby the tobacco is extracted into water. 74646021 Vapers Tongue Cure Revealed -liquid accommodates natural tobacco, natural glycerin, and water. Because of overlap with tobacco legal guidelines and medical drug insurance policies, e-cigarette legislation is being debated[when? In August 2016, the US FDA extended its regulatory power to include e-cigarettes, cigars, and “all different tobacco merchandise”. Most customers are trying to give up smoking, however a large proportion of use is recreational or as a method to get round smoke-free laws. Many people who use e-cigarettes nonetheless smoke, elevating concern that they could be delaying or deterring quitting.

In 2016 the US Department of Transportation banned the use of e-cigarettes on industrial flights. The revised EU Tobacco Products Directive came into impact in May 2016, offering stricter regulations for e-cigarettes. It limits e-cigarette advertising in print, on tv and radio, along with decreasing the extent of nicotine in liquids and reducing the flavors used.

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The research followed nearly 4000 healthcare workers and different key workers who had been tested weekly since December. Those who received “breakthrough” infections after one or two doses of vaccine had forty per cent less virus of their our bodies and spent 2.three fewer days in bed than people who had not been vaccinated. Pfizer/BioNTech covid-19 vaccine in Australia are expected to gradual the country’s rollout through June and July. The delay is partly as a result of recently updated well being recommendation in Australia, which suggests the Oxford/AstraZeneca covid-19 vaccine is now not recommended for individuals aged 59 and under. Principle research will evaluate individuals given the drug, called ivermectin, to those receiving traditional care. There will also be buses providing vaccines touring around Dudley, Colchester, Ipswich and elsewhere.

Our World In Data, more than 796.3 million individuals globally have received no less than one dose of a covid-19 vaccine. Our World In Data, more than 807.2 million folks globally have received a minimum of one dose of a covid-19 vaccine. Our World In Data, more than 840.9 million folks globally have acquired no less than one dose of a covid-19 vaccine. Our World In Data, more than 851.9 million individuals globally have received no much less than one dose of a covid-19 vaccine. Our World In Data, more than 863 million individuals globally have received no less than one dose of a covid-19 vaccine. Our World In Data, greater than 871.8 million people globally have acquired no less than one dose of a covid-19 vaccine.

A photograph ID is now required to buy e-cigarettes, and their sale in all-ages merchandising machines just isn’t permitted within the US. Nasty Juice Asap Grape 50ml -cigarette and tobacco firms have recruited lobbyists in an effort to stop the US FDA from evaluating e-cigarette merchandise or banning present products already in the marketplace.
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Local governments could regulate vaping more stringently than the state. Instead, vaping is prohibited solely on MARC commuter rail system trains. All different indoor places, including bars and restaurants, that are topic to the Maryland Clean Indoor Air Act are totally exempt from the state’s vaping laws. Each time a new reminiscence is created or a new ability is realized, stronger connections – or synapses – are built between mind cells. Because dependancy is a type of learning, adolescents can get addicted more easily than adults.
According to National Health Interview Survey information from 2014 to 2017, 38.9% of pregnant smokers used e-cigarettes in comparison with solely thirteen.5% of non-pregnant, reproductive age women people who smoke. A well being financial study found that passing an e-cigarette minimal authorized sale age law in the United States elevated teenage prenatal smoking by zero.6 percentage points and had no impact on delivery outcomes. Nevertheless, additional analysis needs to be accomplished on the health results of electronic cigarette use during being pregnant.
In 2001, he considered utilizing a excessive frequency, piezoelectric ultrasound-emitting factor to vaporize a pressurized jet of liquid containing nicotine. Hon said that utilizing resistance heating obtained higher results and the problem was to scale down the device to a sufficiently small measurement. Hon Lik sees the e-cigarette as comparable to the “digital camera taking up from the analogue digicam.” The earliest e-cigarette may be traced to American Herbert A. Gilbert, who in 1963 utilized for a patent for “a smokeless non-tobacco cigarette” that concerned “changing burning tobacco and paper with heated, moist, flavored air”.

Although some manufacturers have begun recycling companies for their e-cigarette cartridges and batteries, the prevalence of recycling is unknown. E-cigarettes that aren’t reusable contribute to the problem of electronic waste, which can create a hazard for individuals and other organisms. Most incidents in which electronic cigarettes have been identified to blow up, occurred when the system itself is charging, often inside 10 minutes. When an e-cigarette combusts, it creates a fire hazard, especially if the digital cigarette is left by itself with no supervision. Multiple case studies have shown that electronic cigarettes are vulnerable to this while they’re charging. The U.S. Fire Administration states that “E-cigarettes left charging for an extended period, especially when unattended, have led to fires in houses and automobiles,” .
The drug use should be “implicated” within the emergency division visit, however doesn’t need to be the direct reason for the visit. Most of the illicit drug emergency room visits concerned a quantity of medication. A 2016 Cochrane review mentioned that cannabinoids have been “most likely effective” in treating chemotherapy-induced nausea in kids, however with a high side-effect profile . Less frequent unwanted effects were “ocular problems, orthostatic hypotension, muscle twitching, pruritus, vagueness, hallucinations, lightheadedness and dry mouth”. The Cannabis plant has a historical past of medicinal use dating again 1000’s of years in lots of cultures. Some American medical organizations have requested elimination of cannabis from the list of Schedule I managed substances maintained by the United States federal government, adopted by regulatory and scientific evaluate.
Nicotine habit is a dysfunction which alters totally different neural methods such as dopaminergic, glutamatergic, GABAergic, serotoninergic, that participate in reacting to nicotine. Long-term nicotine use affects a broad vary of genes associated with neurotransmission, sign transduction, and synaptic architecture. The ability to quitting smoking is affected by genetic components, together with genetically based mostly variations in the greatest way nicotine is metabolized. Instead, vaping is prohibited only in public instructional amenities and on grounds thereof. All different indoor places that are covered by the New Hampshire Clean Indoor Air Act, including bars and eating places, are completely exempt from the state’s rules. Localities are prohibited from regulating vaping more stringently as they’re prohibited from regulating smoking extra stringently. Some folks get CBD by smoking the flowering parts of the hemp plant, much like the finest way individuals could smoke marijuana in rolled cigarettes.
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Iowa City, July 16, 2015, banned in all enclosed workplaces, together with bars and eating places or selling to minors. Topicals are rubbed instantly onto sore muscular tissues or joints, the place they might ease ache by reducing inflammation, Earleywine says. CBD balms usually embrace extracts blended right into a fats, similar to beeswax or coconut oil. That recipe not only makes it easier to unfold the product on your skin but in addition permits the CBD to penetrate. Several folks in CR’s current survey also stated CBD helped them cope with a variety of well being problems. Ashley Garris, 28, of Wilmington, N.C., says she began using CBD three months ago to treat her fibromyalgia, anxiousness, and headaches.
There cannot be a defensible reason for hurt discount in children who’re vaping with a base of nicotine. Quitting smoking is essentially the most effective technique to tobacco hurt reduction. For people who smoke who’re unable or unwilling to give up using typical smoking cessation strategies such as nicotine alternative remedy , vaping has a task in tobacco hurt reduction. Research suggests that e‐cigarettes may help folks to stop smoking cigarettes.

This is much like tobacco trade exercise going again to the 1980s. These approaches had been utilized in Europe to minimize the EU Tobacco Products Directive in October 2013. Grassroots lobbying additionally influenced the Tobacco Products Directive choice. Tobacco companies have labored with organizations conceived to promote e-cigarette use, and these organizations have worked to hamper laws intended at limiting e-cigarette use. Harm reduction refers to any reduction in hurt from a prior degree. Harm minimization strives to scale back harms to the bottom achievable stage.
In common there are far decrease dangers of pulmonary issues for regular cannabis smokers when compared with those of tobacco. Combustion merchandise aren’t current when using a vaporizer, consuming THC in capsule kind, or consuming cannabis edibles. Medical hashish could be administered through various methods, including capsules, lozenges, tinctures, dermal patches, oral or dermal sprays, cannabis edibles, and vaporizing or smoking dried buds.

However, oral administration of CBD has a sooner time to peak concentrations than THC. Inhaled and vaporized THC have related absorption profiles to smoked THC, with a bioavailability ranging from 10 to 35%. Oral administration has the bottom bioavailability of roughly 6%, variable absorption depending on the automobile used, and the longest time to peak plasma ranges compared to smoked or vaporized THC. A 2011 evaluate thought of cannabis to be usually secure, and it seems safer than opioids in palliative care. When hashish is inhaled to alleviate ache, blood levels of cannabinoids rise quicker than when oral products are used, peaking within three minutes and attaining an analgesic effect in seven minutes.
Large tobacco corporations have acquired a few of the e-cigarette firms.Tobacco companySubsidiary companyElectronic cigaretteImperial TobaccoFontem Ventures and DragonitePuritane blu eCigsBritish American TobaccoCN Creative and NicoventuresVypeR. J. Reynolds Tobacco CompanyR. J. Reynolds Vapor CompanyVuseAltria ∗No longer sells e-cigarettes. In 1927, Joseph Robinson utilized for a patent for an electronic vaporizer for use with medicinal compounds. The patent was accredited in 1930 but the device was never marketed. The reinforcing results of addictive drugs, corresponding to nicotine, are associated with its capacity to excite the mesolimbic and dopaminergic systems. E-cigarette use is highest in China, the US, and Europe, with China having probably the most e-cigarette customers.
  • In April 2014 the US FDA revealed proposed rules for e-cigarettes.
  • Philip Morris International’s IQOS device with charger and tobacco stick.
  • A 2016 World Health Organization report discovered that the scientific proof for the effectiveness of vaping for quitting smoking is “scant and of low certainty”.
  • In dozens of states, health food stores, pharmacies, and even supermarkets and restaurants are carrying CBD merchandise.

Common unwanted effects include dizziness, feeling tired, vomiting, and hallucinations. Concerns include memory and cognition issues, threat of addiction, schizophrenia in younger people, and the danger of youngsters taking it accidentally. Instead, vaping is just prohibited in Department of Corrections facilities and on grounds thereof, by both employees and inmates. All other indoor places, including bars and eating places, are totally exempt from the state’s rules, and it remains unclear whether or not or not native government are allowed to manage their utilization extra stringently. Instead, vaping is prohibited solely on all properties of State Executive Branch, including buildings, automobiles, and land, however excluding particular outside areas such as parks, Kentucky Horse Park, and Kentucky State Fairgrounds.
Fruit flavored e-liquid is probably the most generally marketed e-liquid taste on social media. Massive promoting included the assertion that they might present little threat to non-users. Though, “disadvantages and unwanted effects have been reported in plenty of articles, and the unfavorable results of its secondhand vapor have been demonstrated in many studies”, and proof indicates that use of e-cigarettes degrades indoor air quality. Many e-cigarette firms market their products as a smoking cessation assist without evidence of effectiveness. E-cigarette advertising has been found to make unsubstantiated health statements (e.g., that they assist one give up smoking) including statements about enhancing psychiatric signs, which can be significantly interesting to smokers with mental illness. E-cigarette marketing advocate weight control and emphasize use of nicotine with many flavors. These marketing angles might significantly entice overweight individuals, youth, and vulnerable teams.

The on-line forum was one of many first major communities. It and different online forums, corresponding to, were the place the interest of modding began. Online boards based round modding have grown in the vaping community.
Soon after the clearomizer reached the market, replaceable atomizer coils and variable voltage batteries were introduced. Clearomizers and eGo batteries became the best-selling customizable e-cigarette elements in early 2012. Initially, their performance did not meet the expectations of users. The e-cigarette continued to evolve from the first-generation three-part device.
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Some e-cigarette companies state that their merchandise are green without supporting evidence which can be purely to increase their gross sales. The core concern is that people who smoke who may have give up totally will develop an alternate nicotine addiction. Dual use could additionally be an elevated threat to a smoker who continues to use even a minimal quantity of conventional cigarettes, somewhat than quitting. The promotion of vaping as a harm discount assist is untimely, while a 2011 review discovered they seem to have the potential to decrease tobacco-related dying and illness. Evidence to substantiate the potential of vaping to decrease tobacco-related death and illness is unknown.
In 2019 and 2020, an outbreak of severe vaping lung illness within the US was strongly linked to vitamin E acetate by the CDC. E-cigarettes produce similarly high levels of particulates in the air as do tobacco-cigarettes. There is “solely limited proof displaying opposed respiratory and cardiovascular results in humans”, with the authors of a 2020 evaluation calling for extra long-term research on the topic. A 2020 evaluation discovered e-cigarettes improve the risk of bronchial asthma by 40% and persistent obstructive pulmonary disease by 50%. The “catalyst mannequin” suggests that vaping may proliferate smoking in minors by sensitizing minors to nicotine with the use of a kind of nicotine that’s extra pleasing and with out the adverse attributes of regular cigarettes. There is insufficient knowledge to draw sturdy conclusions about the security of medical hashish.
The powerful edibles are a fun and handy way to get your every day dose of CBD and help you discover what products and doses work greatest for you. Hemp CBD Gummies don’t at all times work for everybody, and it’s essential to be patient and open minded about your personal CBD experience. Yes, each merchandise offered by JustCBD, corresponding to CBD edibles, oils and vapes, are legal wick liquor boulevard shattered 50ml within the U.K. CBD merchandise are thought of food-based, and our products don’t produce a psychoactive impact. If you are trying CBD for the primary time, CBD gummies are a safe, quick and efficient means of taking CBD. MARTIN COX, forty eight, of Couldrey Close, Abingdon, admitted breaching a felony behaviour order made by Oxford Magistrates’ Court on October 8, by consuming alcohol in a public place in Abingdon on March 29.
In 2021 the US PSTF concluded the evidence continues to be insufficient to advocate e-cigarettes for quitting smoking, discovering that the balance of advantages and harms can’t be decided. As of January 2018, systematic critiques collectively agreed that there’s inadequate evidence to unequivocally determine whether vaping helped people abstain from smoking. A 2020 systematic evaluate and meta-analysis of sixty four studies found that on the entire as shopper products e-cigarettes don’t enhance quitting smoking. E-cigarettes containing nicotine have been listed as drug supply units in a quantity of countries, and the marketing of such products has been restricted or placed on hold till safety and efficacy clinical trials are conclusive. Since they don’t include tobacco, tv advertising in the US just isn’t restricted. Some nations have regulated e-cigarettes as a medical product even though they have not accredited them as a smoking cessation aid.

It requires the purchaser for e-cigarettes to be a minimum of 18 and does not allow shopping for them for anybody lower than 18 years of age. The updated Tobacco Products Directive has been disputed by tobacco lobbyists whose companies might be impacted by these revisions. As of 8 August 2016, the US FDA extended its regulatory energy to incorporate e-cigarettes, e-liquid and all related merchandise. Under this ruling the FDA will evaluate certain issues, including components, product features and well being risks, as well their enchantment to minors and non-users.
“But the detection of antibodies alone just isn’t a precise measure of the immunity protection given by vaccination,” says the ONS. The survey also discovered that per cent of adults said they’d received one dose of the vaccine and per cent stated they had had each doses. Washington State Ferries forbids vaping on its vessels as per an announcement given on every crusing. A four month ban on flavored vaping merchandise was enacted in October 2019. On November 22, 2017, a legislation went into impact prohibiting vaping all over the place that smoking is banned, together with all enclosed workplaces, bars and restaurants.

Compared to many alternative quitting smoking medicines in early growth in scientific trials together with e-cigarettes, cytisine will be the most encouraging in efficacy and security with a reasonable worth. Other sorts of nicotine substitute products are normally coated by health methods, however as a result of e-cigarettes aren’t medically licensed they are not covered.
Hancock additionally said there was never a national scarcity of personal protecting tools for medical employees, despite stories of doctors and nurses having been compelled to improvise. “We’ve looked into this and there’s no proof that I even have seen that a scarcity of PPE provision led to anybody dying of covid,” he stated. The delta variant first recognized in India is now inflicting 91 per cent of coronavirus infections in the UK, stated well being secretary Matt Hancock. He told MPs this was based on an evaluation he noticed on Wednesday night. Hancock was talking throughout more than four hours of questioning by MPs on the science and health committees. A spokesperson from the European Commission said that member states may make their own decisions on whether to permit entry for individuals who have acquired vaccines on the WHO’s emergency authorisation listing, which incorporates Covishield.
Statewide vaping ban As of June 2016, e-cigarettes are included in California’s smokefree laws. E-cigarette use is prohibited in workplaces and lots of public spaces, including restaurants and bars.
Delta-9-THC is the first molecule answerable for the results of cannabis. Delta-9-THC is metabolized in the liver and turns into 11-OH-THC.11-OH-THC is the first metabolic product on this pathway. The metabolism of THC into 11-OH-THC performs a component within the heightened psychoactive results of edible hashish. The most psychoactive cannabinoid discovered in the hashish plant is tetrahydrocannabinol (or delta-9-tetrahydrocannabinol, commonly often recognized as THC). Other cannabinoids embody delta-8-tetrahydrocannabinol, cannabidiol , cannabinol , cannabicyclol , cannabichromene and cannabigerol ; they have much less psychotropic results than THC, however might play a job within the overall impact of cannabis. According to the United States Department of Health and Human Services, there were 455,000 emergency room visits related to hashish use in 2011. These statistics include visits by which the affected person was handled for a situation induced by or associated to current hashish use.
Vapers embrace actions related to e-cigarettes and typically evangelise for them. E-cigarette firms have a substantial on-line presence, and there are english mint premium e liquid by e luxe london 3mg nicotine 50vg 50pg many individual vapers who blog and tweet about e-cigarette associated products.

Some research that controls for confounding components finds that vaping is an “exit ramp” from smoking. In different phrases, somewhat than leading to more cigarette smoking, e-cigarette use could also be resulting in much less smoking. However other research that controls for confounding components finds that vaping increases odds of later smoking. A 2011 systematic evaluation evaluated printed studies of the acute and long-term cognitive effects of hashish. THC intoxication is properly established to impair cognitive functioning on an acute foundation, including effects on the power to plan, organize, remedy issues, make choices, and control impulses.
There has been a limited number of research which have seemed on the results of smoking hashish on the respiratory system. Chronic heavy marijuana smoking is related to coughing, manufacturing of sputum, wheezing, coughing, and different symptoms of continual bronchitis. Regular hashish use has not been shown to trigger vital abnormalities in lung function.
There is concern that youngsters might progress from vaping to smoking. Adolescents are prone to underestimate nicotine’s addictiveness. Vulnerability to the brain-modifying results of nicotine, along with youthful experimentation with e-cigarettes, may lead to a lifelong dependancy.

Author Biography: Elena Ognivtseva

Author Biography: Elena Ognivtseva

Elena is an avid blogger who enjoys writing articles on fashion, beauty, lifestyle, fitness and recently, CBD niches. Elena has been described as a "delightfully eccentric with a creative take on things" (New York Times) with an ability to "bring you new facts that will make you go WOW!" (Vanity Fair). Elena has been writing since her uni days where she was a regular contributor to the student magazine. After pursuing a career in finance in the heart of London's financial hub, Elena has decided to start blogging in her spare time as an outlet for her creativity and ideas. During her spare time, Elena enjoy horse riding, camping and hiking, interior design and keeping abreast with the latest trends. Elena is in the process of starting up her own beauty cosmetics line in the near future. Elena is also a contributing author to fashion and lifestyle magazines and has been featured in Vice, Country Living, Harrods magazine, Daily Telegraph, Grazia and Women's Health.